Fast Company reached out to Nasty Gal for further comment, and they said they have none at this time.Still, the people let go accounted for every expectant or recent parent on staff, according to anonymous statements from former Nasty Gal employees to Jezebel. Regardless of the company intent or the validity of the employees claims, the report is a blow to a female led company that has built much of its reputation on the empowerment of young women.Nasty Gal founder Sophia Amoruso has been praised as a model of the 21st century entrepreneur: directionless as a teenager, she hit upon a brilliant approach to selling clothes on eBay, and without formal business training turned it into a company that attracted $65 million in outside funding and generates $100 million in annual revenue at last report. Even more critically, she been credited with setting a strong example for young ambitious women with her self made success, which she chronicled in memoir/advice book GIRLBOSS last year.
Bioinformatics and luciferase analyses showed that miR 199a negatively but directly regulates FOXA2 expression through binding in its 3 untranslated region (UTR). Evaluation of the functional importance of miR 199a on pancreatic cancer revealed that miR 199a acts as an inhibitor of FOXA2 expression, inducing an increase in pancreatic cancer cell proliferation, migration, and invasion. Additionally, gene ontology and network analyses in PANC 1 cells treated with a small interfering RNA (siRNA) against FOXA2 revealed an enrichment for cell invasion mechanisms through PLAUR and ERK activation.
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